期刊
TETRAHEDRON
卷 64, 期 17, 页码 3859-3866出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2008.01.086
关键词
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An efficient total synthesis of the S1P(1) agonist, KRP-203, is described. The key step involves the conjugate addition of diethyl acetamidomalonate to a styrene compound to give the core structure of KRP-203. Multigram quantities of the targeted KRP-203, sufficient for several biological studies, were obtained in six steps with an overall yield of 58%. (c) 2008 Elsevier Ltd. All rights reserved.
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