期刊
TALANTA
卷 190, 期 -, 页码 263-268出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.talanta.2018.07.071
关键词
Methylamphetamine; Au@Ag; Aptamer; SERS, illicit drug of abuse
资金
- Natural Science Foundation of China (NSFC) [41371442, 41401566]
- UK NERC personal fellowship grant [NE/R013349/1]
- NERC [NE/R013349/1] Funding Source: UKRI
We describe a novel biosensing strategy for sensitive detection of methylamphetamine (MAMP) based on surface enhanced Raman scattering (SERS) by the mediation of spacing between 4-mercaptobenzoic acid (4-MBA) labeled Au@Ag core-shell nanoparticles (Au@Ag). To achieve a favorable SERS substrate, Au@Ag shell-core nanoparticle was synthesized with seeds growth method and well characterized by SEM, TEM and UV-vis spectrometer. The uniform Au@Ag shows an excellent dispersion ability for SERS detection. Under the optimized conditions, the novel biosensor shows a good logarithm linear correlation with the concentration of MAMP ranging from 0.5 ppb to 40 ppb (R-2 = 0.986), with a limit of detection at 0.16 ppb of MAMP (3 sigma). Furthermore, our biosensors hold an excellent selectivity, demonstrated by the negligible interference from the detection of other illicit drugs and metabolites. The concentrations determined with our biosensor from spiked MAMP in human urine sample fell within the same range with the results from mass spectrometry. This indicates that our sensor has a clear potential for the rapid detection of illicit drug in real samples.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据