期刊
TALANTA
卷 122, 期 -, 页码 36-42出版社
ELSEVIER
DOI: 10.1016/j.talanta.2013.12.008
关键词
Gold nanoclusters; Tetracycline; Enhanced fluorescence; Detection
资金
- National Natural Science Foundation of China [31100981]
- Research Fund for the Doctoral Program of Higher Education of China [20110182120014]
- Natural Science Foundation Project of CQ CSTC [cstc2013jcyjA10117]
- Fundamental Research Funds for the Central Universities [XDJK20138038]
Tetracycline and Eu3+, while coexisting, usually appear as a complex by chelating. This complex shows low fluorescence intensity, leading to its limitation of analytical goals. Gold nanoclusters (AuNCs), emerging as novel nano-material, are attracting increasing attentions in multiple fields. Herein, gold nanoclusters first function as a fluorescence-enhanced reagent rather than a conventional fluorescent-probe, and a dramatic enhanced-fluorescence system was built based on Eu3+-Tetracycline complex (EuTC) by introducing gold nanoclusters. Simultaneously, three types of gold nanoclusters were employed for exploring various conditions likely affecting the system, which demonstrate that no other gold nanoclusters than DNA-templated gold nanoclusters enormously caused fluorescence-enhancement of EuTC. Moreover, this enhanced-fluorescence system permitted available detection of tetracycline (TC) in a linear range of 0.01-5 mu M, with a detection limit of 4 nM at a signal-to-noise ratio of 3. Significantly, the practicality of this method for detection of TC in human urine and milk samples was validated, demonstrating its advantages of simplicity, sensitivity and low cost. Interestingly, this system described here is probably promising for kinds of applications based on its dramatically enhanced-fluorescence. (C) 2013 Elsevier B.V. All rights reserved.
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