Non-enzymatic glucose sensors based on controllable nanoporous gold/copper oxide nanohybrids

A kind of dealloyed nanoporous gold (NPG)/ultrathin CuO film nanohybrid for non-enzymatic glucose sensing has been prepared by a simple, in-situ, time-saving and controllable two-step electrodeposition. The three-dimensional and bicontinuous nanoporous structure of the nanocomposites have been characterized by scanning electron microscope (SEM) and transmission electron microscopy (TEM), and the electrochemical tests have been estimated by cyclic voltammetry and single potential step chronoamperometry (SPSC). The optimal NPG/CuO electrode exhibits great electrocatalytic activity towards glucose oxidation and also shows obvious linear response to glucose up to 12 mM with a high sensitivity of 374.0 mu A cm(-2) mM(-1) and a good detection limit of 2.8 mu M (S/N=3), as well as strong tolerance against chloride poisoning and interference of ascorbic acid and uric acid. (C) 2014 Elsevier B.V. All rights reserved.