期刊
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
卷 12, 期 10, 页码 12924-12940出版社
MDPI
DOI: 10.3390/ijerph121012924
关键词
air pollution; PM2.5; PM10; carotid intima-media thickness; subclinical atherosclerosis; meta-analysis
资金
- Beijing Municipal Science and Technology Commission [Z131107002213176]
- National 973 Project [2015CB553400]
- National Environmental Protection Non-profit Project [2015003016]
- National Natural Science Foundation [41450006]
- Beijing Medical Health Science and Technology Key-support Project [2014-1-4016]
Background: Long time exposure to particular matter has been linked to myocardial infarction, stroke and blood pressure, but its association with atherosclerosis is not clear. This meta-analysis was aimed at assessing whether PM2.5 and PM10 have an effect on subclinical atherosclerosis measured by carotid intima-media thickness (CIMT). Methods: Pubmed, Ovid Medline, Embase and NICK between 1948 and 31 March 2015 were searched by combining the keywords about exposure to the outcome related words. The random-effects model was applied in computing the change of CIMT and their corresponding 95% confidence interval (95% CI). The effect of potential confounding factors was assessed by stratified analysis and the impact of traffic proximity was also estimated. Results: Among 56 identified studies, 11 articles satisfied the inclusion criteria. In overall analysis increments of 10 g/m(3) in PM2.5 and PM10 were associated with an increase of CIMT (16.79 m; 95% CI, 4.95-28.63 m and 4.13 m; 95% CI, -5.79-14.04 m, respectively). Results shown in subgroup analysis had reference value for comparing with those of the overall analysis. The impact of traffic proximity on CIMT was uncertain. Conclusions: Exposure to PM2.5 had a significant association with CIMT and for women the effect may be more obvious.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据