期刊
TALANTA
卷 116, 期 -, 页码 978-984出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.talanta.2013.08.015
关键词
Surface enhanced Raman scattering; Magnetic; Fluorescence; Onion-liked structure; Multi-mode; Cell imaging
资金
- Natural Science Foundation of China (NSFC) [60708024, 60877024, 61177033, 21104009]
- Specialized Research Fund for the Doctoral Program of Higher Education (SRFDP) [20070286058, 20090092110015]
- Science Foundation for The Excellent Youth Scholars of Southeast University
- Scientific Research Foundation of Graduate School of Southeast University [YBJJ1125]
- Fundamental Research Funds for the Central Universities
A magnetically controllable dual-mode optical probe is demonstrated for cellular imaging with an onion-liked structure, which can exhibit both surface enhanced Raman scattering (SERS) and fluorescence signals. For obtaining such a nanoprobe, Fe3O4 nanoparticles were first encapsulated into an inner layer of silica, which were then coated with a second layer of gold nanoshell (designated as Fe3O4@SiO2@Au). By adjusting the thickness of the gold shell, the surface plasmon resonance (SPR) of Fe3O4@SiO2@Au nanoparticles can be easily tuned from visible to near-infrared (NIR) region. Afterwards, the prepared Fe3O4@SiO2@Au nanoparticles were tagged with a third layer of Raman reporters to exhibit SERS signals and further coated with an outmost layer of dye-doped silica to generate fluorescence. When being excited at different wavelengths as 515 nm and 633 nm, the distinct fluorescence and SERS signals can be separately observed. More interestingly, an enhanced cellular uptake of the presented nanoprobes was observed in the presence of a magnetic field, which was proved by both fluorescence and SERS images. This onion-liked multi-modal nanoplatform has great potential in bio-imaging, targeted delivery applications and biological separations. (C) 2013 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据