期刊
TALANTA
卷 83, 期 3, 页码 765-769出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.talanta.2010.10.041
关键词
Phenazopyridine; Molecularly imprinted polymer; Solid-phase extraction; Ion mobility spectrometry
资金
- research Affairs Division and Research Council and Center of Excellency in Sensor and Green Chemistry of Isfahan University of Technology (IUT)
In this research, selective separation and determination of phenazopyridine (PAP) is demonstrated using molecular imprinted polymer (MIP) coupled with electrospray ionization ion mobility spectrometry (ESI-IMS). In the non-covalent approach, selective MIP produced using PAP and methacrylic acid (MAA) as a template molecule and monomer, respectively. The created polymer is utilized as a media for solid-phase extraction (SPE), revealing selective binding properties for the analyte from pharmaceutical and serum samples. A coupled MIP-IMS makes it possible to quantitize PAP in the range of 1-100 ng mL(-1) and with a 0.2 ng mL(-1) detection limit. Furthermore, the MIP selectivity is evaluated by application of some substances with analogous and different molecular structures to that of PAP. This method is successfully applied for the determination of PAP in pharmaceutical and serum samples. (C) 2010 Elsevier B.V. All rights reserved.
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