期刊
TALANTA
卷 85, 期 3, 页码 1665-1671出版社
ELSEVIER
DOI: 10.1016/j.talanta.2011.06.070
关键词
Neutral desorption (ND); Extractive electrospray ionization (EESI); Viscous samples; Cream; Sunscreen agents; High throughput analysis
资金
- Innovation Method Fund of China [2008IM40400]
- MOST of China [2009DFA30800]
High throughput analysis of sunscreen agents present in cream cosmetic has been demonstrated, typically 2 samples per minute, using neutral desorption extractive electrospray ionization mass spectrometry (ND-EESI-MS) without sample pretreatment. For the targeted compounds such as 4-Aminobenzoic acid and oxybenzone, ND-EESI-MS method provided linear signal responses in the range of 1-100 ppb. Limits of detection (LOD) of the method were estimated at sub-ppb levels for the analytes tested. Reasonable relative standard deviation (RSD = 8.4-16.0%) was obtained as a result of 10 independent measurements for commercial cosmetics samples spiked with each individual sunscreen agents at 1-10 ppb. Acceptable recoveries were achieved in the range of 87-116% for direct analysis of commercial cream cosmetic samples. The experimental data demonstrate that ND-EESI-MS is a useful tool for high throughput screening of sunscreen agents in highly viscous cream cosmetic products, with the capability to obtain quantitative information of the analytes. (C) 2011 Elsevier B.V. All rights reserved.
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