期刊
TALANTA
卷 80, 期 5, 页码 1713-1718出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.talanta.2009.10.011
关键词
Molecularly imprinted polymer; Cinchonidine; Precipitation polymerization; Core-shell polymer; Stereoisomer separation
资金
- Ministry of Education, Culture. Sports, Science and Technology, Japan [19390013]
- Grants-in-Aid for Scientific Research [19390013] Funding Source: KAKEN
Three monodispersed, molecularly imprinted polymers (MIPs) for cinchonidine (CD) have been synthesized by precipitation polymerization MIP1 was prepared using methacrylic acid (MAA) as a functional monomer and divinylbenzene (DVB) as a cross-linker and MIP2 was prepared with further addition of 2-hydroxyethyl methacrylate (HEMA) as a co-monomer. For the preparation of MIP3, core-shell type MIP, monodispersed DVB homopolymers, which are prepared by precipitation polymerization, were used as a core and CD-imprinted MAA-DVB copolymer phases were coated onto the core. Three MIPs synthesized gave monodispersed, spherical beads in micrometer sizes. The binding characteristics and molecular recognition properties of MIP1-3 were examined by Scatchard analysis and chromatographic studies The association constant of CD with MIP1 was the highest among MIPs prepared, while that with MIP3 was the lowest. The template molecule, CD, was more retained than its stereoisomer, cinchonine, on the three MIPs, and the stereoseparation factor of 38 was obtained with MIP3. (C) 2009 Elsevier B.V. All rights reserved.
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