期刊
TALANTA
卷 77, 期 1, 页码 319-324出版社
ELSEVIER
DOI: 10.1016/j.talanta.2008.06.040
关键词
Polythiophene derivative; Gold nanoparticles; Aspartic acid and glutamic acid; Fluorometry
资金
- National Science Foundation of China [20575046]
- NSFC [20621502]
- Innovative Research Team in University [IRT0543]
- National Key Scientific Program-Nanoscience and Nanotechnology [2006CB933103]
In recent years, gold nanoparticles and water-soluble fluorescent conjugated polymers are promising materials in terms of their potential applications in a variety of fields, ranging from monitoring DNA hybridization to demonstrate the interaction between proteins, or detecting diseased cell, metal ions and small biomolecular. In order to exploit some new properties of the both, many attempts have been devoted to achieve nanoparticle-polymer composite via incorporating metal nanoparticle into polymer or vice versa, however, only few of them are put into practical application. In the present paper, we utilize the superquenching property of AuNPs to polythiophene derivatives for detecting aspartic acid (Asp) and glutamic acid (Glu) in pure water, and discuss the factors accounting for fluorescence quenching and recovery via modulating pH. Thus an exceptionally simple, rapid and sensitive method for detecting Asp and Glu is established with a limit of detection (LOD) is 32 nM for Asp and 57 nM for Glu, the linear range of determination for Asp is 7.5 x 10(-8) M to 6 x 10(-6) M and 9.0 x 10(-8) M to 5 x 10(-6) M for Glu. The system is applied to real sample detection and the results are satisfying. Otherwise the composite is very sensitive to pH change of solution, we expect it will be possible to use as pH sensor with wide range in the future. (c) 2008 Elsevier B.V. All rights reserved.
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