Simultaneous use of mifepristone and misoprostol for early pregnancy termination

Objective: Simultaneous mifepristone 200 mg and vaginal misoprostol 800 mu g produces a complete abortion rate of approximately 90% at up to 63 days of gestation. The aim of this study was to determine the effectiveness of concurrent administration of mifepristone 200 mg and vaginal misoprostol 600 mu g with respect to early medical abortion. Materials and Methods: A total of 254 women with undesired pregnancies of less than 49 days of gestation were enrolled. All women received oral mifepristone 200 mg and vaginal misoprostol 600 mu g concurrently. Follow-up assessment by transvaginal ultrasonography was performed 3 days and 2 weeks after treatment. Results: Efficacy outcome was analyzed for 242 women (95.3%) after excluding 12 individuals lost to follow-up. The complete abortion rate was 92.6%. The mean induction to abortion interval was about 5.8 hours. The mean bleeding duration was about 12.6 days. The women indicated that the side effects were tolerable and 90% of them said that their experience was satisfactory. Conclusion: Concurrent administration of oral mifepristone 200 mg and vaginal misoprostol 600 mu g is an efficacious regimen for medical abortion of pregnancies up to 49 days of gestation. Copyright (C) 2011, Taiwan Association of Obstetrics & Gynecology. Published by Elsevier Taiwan LLC. All rights reserved.