期刊
HUMAN VACCINES & IMMUNOTHERAPEUTICS
卷 11, 期 4, 页码 1030-1035出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/21645515.2015.1009809
关键词
interleukin-10; HIV-1; mouse; T cells
资金
- John Fell OUP Research Fund
- Doctoral Training Award from the Nuffield Department of Medicine, University of Oxford
- MRC [G1001757, MC_U137884179] Funding Source: UKRI
- Medical Research Council [MC_U137884179, G1000800d, G1001757] Funding Source: researchfish
- The British Council [172735957] Funding Source: researchfish
Viral vector vaccines designed to elicit CD8(+) T cells in non-human primates exert potent control of immunodeficiency virus infections; however, similar approaches have been unsuccessful in humans. Adenoviral vectors elicit potent T cell responses but also induce production of immunosuppressive interleukin-10 (IL-10), which can limit the expansion of T cell responses. We investigated whether inhibiting IL-10 signaling prior to immunization with a candidate adenovirus vectored-HIV-1 vaccine, ChAdV63.HIVconsv, could modulate innate and adaptive immune responses in BALB/c mice. Transient IL-10 receptor blockade led to a modest but significant increase in the total magnitude CD8(+) T cell response to HIVconsv, but did not affect T cell responses to immunodominant epitopes. Anti-IL-10R-treated animals also exhibited greater expression of CD86 on CD11c(+) dendritic cells. Our data support further investigation and optimization of IL-10 blocking strategies to improve the immunogenicity of vaccines based on replication-defective adenoviruses.
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