期刊
SYNTHETIC COMMUNICATIONS
卷 45, 期 1, 页码 70-77出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/00397911.2014.952307
关键词
Asymmetric catalysis; chiral macrocycles; enantioselective sulfoxidation; esomeprazole
资金
- Zhejiang Provincial Top Key Academic Discipline of Chemical Engineering and Technology, Zhejiang Sci-Tech University [YR2013012]
An efficient synthesis of esomeprazole via catalytic asymmetric oxidation of 1H-benzimidazolyl pyridinylmethyl sulfide by a titanium complex with a hexa-aza-triphenolic macrocycle ligand is described. Esomeprazole was prepared with 99.6% ee, which meets the high requirement of the European Pharmacopeia on enantiomeric purity.
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