期刊
SYNTHETIC COMMUNICATIONS
卷 44, 期 19, 页码 2756-2788出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/00397911.2014.926374
关键词
Coumarin derivatives; efficient method; heterogeneous catalysts; high yield; ionic liquid; Knoevenagel condensation; piperidine
资金
- University Grants Ccommission-BSR
The synthesis of coumarins through Knoevenagel condensation is one of the most important processes in synthetic organic chemistry and medicinal chemistry. Compounds including a coumarin (2-oxo-2H-1-benzopyran) backbone have a wide range of application in the pharmaceutical field. Thus, many methodologies have been developed for the synthesis of this important class of compounds. However, some methods are always associated with toxic and corrosive catalysts, longer reaction time, poor yield, less purity, and by-products along with the desired product. Furthermore, some of these processes are not efficient and environmentally friendly. Therefore, mild, efficient, and environmentally friendly protocols have been developed recently by many scientists for the synthesis of coumarin derivatives via Knoevenagel condensation with good yield and purity. In this review, we have summarized various methods for the synthesis of coumarins via Knoevenagel condensation.
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