K2S2O8-MEDIATED DIFUNCTIONALIZATION OF CC BONDS IN WATER: A SIMPLE AND EFFICIENT APPROACH TO α,α-DIHALOACETOPHENONES FROM PHENYLACETYLENES AND NaX

A novel K2S2O8-mediated oxy-1,1-dihalogenation of alkynes with NaX in the presence of water has been developed, affording alpha,alpha-dihaloacetophenones in moderate to good yields. The advantages of this reaction are mild reaction conditions, operational simplicity, and use of pure water as reaction medium. A plausible reaction mechanism is proposed on the basis of mechanistic studies.