GREEN PROCESS DEVELOPMENT FOR THE SYNTHESIS OF ALIPHATIC SYMMETRICAL N,N′-DISUBSTITUTED THIOUREA DERIVATIVES IN AQUEOUS MEDIUM

A highly efficient green process for the synthesis of N,N-disubstituted aliphatic thiourea derivatives using primary aliphatic amines and carbon disulfide in an aqueous medium at room temperature via a nonisothiocyanate route is described. This protocol illustrates the rapid preparation of N,N-disubstituted aliphatic thiourea derivatives in excellent yields with some advantages such as no catalyst and simple workup without any side product formation. Moreover, the new route is concise, does not require chromatography, and is adaptable to pilot-scale preparation.