期刊
SYNTHETIC COMMUNICATIONS
卷 43, 期 16, 页码 2127-2133出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/00397911.2012.714830
关键词
Hydroxylammonium chloride; primary amine; reductive amination; zinc
资金
- Compagnie Industrielle de la Matiere Vegetale (CIMV)
- Ministry of Higher Education, Scientific Research, and Technology in Tunisia
We report here a novel, one-pot, two-step reductive amination of aldehydes for the atom-economical synthesis of primary amines. The amination step has been carried out with hydroxylammonium chloride and does not require the use of a base. In the subsequent reduction step, a metal zinc/hydrochloride acid system has been used. This method is applicable to both aliphatic and aromatic aldehydes. The operational simplicity, the short reaction times, and the mild reaction conditions add to the value of this method as a practical alternative to the reductive amination of aldehydes. Supplemental materials are available for this article. Go to the publisher's online edition of Synthetic Communications (R) to view the free supplemental file.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据