EASY ACCESS TO 2-ALKYL AND 2-ARYLTHIAZOLINES USING A MODIFIED HETEROPOLYACID CATALYSIS: APPLICATION TO THE SYNTHESIS OF BACILLAMIDE A

A straightforward access to 2-alkyl and 2-arylthiazolines by condensation of beta-aminothiols on nitriles, catalyzed by phosphotungstic acid (2%) under microwave irradiation, is described. This method has been directly applied to a short and efficient synthesis of bacillamide A (16).