Alkali Salt of L-Proline as an Efficient and Practical Catalyst for the Cyanosilylation of a Wide Variety of Carbonyl Compounds Under Solvent-Free Conditions

The alkali salt of L-proline was demonstrated to be an efficient and practical catalyst for the cyanosilylation of a wide variety of simple and functionalized carbonyl compounds under solvent-free conditions. The reactions proceeded smoothly at room temperature to afford the corresponding cyanohydrins in good to excellent yields.