期刊
SYNTHETIC COMMUNICATIONS
卷 39, 期 4, 页码 733-742出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/00397910802431107
关键词
2-Hydroxy-chalcones; Mannich reaction; microwave-assisted; vasorelaxation
A series of Mannich base derivatives of 2-hydroxy-chalcones were obtained expediently in good to excellent yields by microwave-assisted Mannich reaction. The regioselectivity of the reaction occurred preferentially at the C-3 position of the 2-hydroxy-chalcone backbone. In comparison with conventional results, results from microwave possesses give better yields in shorter times. Further vasorelaxation assay showed that 2-hydroxy-3-((4-methylpiperazin-1-yl)methyl)-4,6-dimethoxymethoxy-3'-bromo-chalcone 8 significantly decreased maximal PE-induced contraction (Emax=1005.97%, EC50=10.20.51M).
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