Synthesis of Second- and Third-Generation Asp Oligopeptide Conjugated Dendrimers for Bone-Targeting Drug Delivery

The second- and third-generation multiple dendrimers based on naproxen in core and Asp(4-6) oligopeptides in periphery were synthesized in a convergent approach and well characterized by NMR and mass spectral (MS) techniques. These conjugates showed a high affinity to hydroxyapatite in vitro and provided an effective entry for the synthesis of a peptide dendrimer used for bone targeting.