期刊
SYNTHETIC COMMUNICATIONS
卷 39, 期 6, 页码 958-979出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/00397910802444258
关键词
AMA; Biginelli; dihydropyrimidinones; methansulfonic acid; recyclable catalysis
资金
- Shiraz University Research Council
- Shiraz Faculty of Pharmacy
Al2O3/CH3SO3H (AMA) is an efficient catalyst for the three-component condensation reaction of aldehyde, 1,3-dicarbonyl compound, and urea or thiourea to afford the corresponding 3,4-dihydropyrimidin-2-(1H)-ones in high isolated yield via this procedure, which works very effectively regardless of the electronic nature of the substituent on the ring, although electron-donating groups precipitate the rate of reaction. The catalyst is recyclable and stable at room temperature, and the reaction protocol is simple, is cost-effective, and gives good isolated yield with high purity.
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