期刊
SYNTHESIS-STUTTGART
卷 46, 期 21, 页码 2910-2916出版社
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0034-1378891
关键词
asymmetric hydrogenation; chiral spiro catalysts; amino ketones; amino alcohols; iridium catalysts
资金
- National Natural Science Foundation of China
- National Basic Research Program of China (973 Program) [2010CB833300]
- '111' project of Ministry of Education of China [B06005]
A highly efficient iridium-catalyzed asymmetric hydrogenation of -amino ketones for the synthesis of chiral 1,2-amino alcohols is described. With chiral spiro iridium catalyst Ir-(R)-1c, a series of -amino ketones were hydrogenated to chiral -amino alcohols in excellent enantioselectivities (up to 99.9% ee) with TON up to 100 000. In addition, with this highly efficient method the chiral drugs (R)-clorpenaline and (R)-phenylephrine were prepared in very high efficiency.
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