期刊
SYNTHESIS-STUTTGART
卷 46, 期 23, 页码 3213-3220出版社
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0034-1378654
关键词
1-aminoisoquinolines; coinage metals; deformylation; 2-alkynylbenzaldoximes; isocyanoacetates
资金
- National Natural Science Foundation of China [21262018, 20862007, 21202065]
- Natural Science Foundation of Jiangxi Province [2010GZH0070]
An efficient reaction of 2-alkynylbenzaldoximes with 2-isocyanoacetates cocatalyzed by silver triflate and gold(I) chloride is described, providing 1-aminoisoquinolines in good to excellent yields under mild conditions. Mechanistic experiments suggest that the gold(I) cation might play a crucial role in the activation of the isocyanide substrate. The observed reactivity and the unique pathway of substrate activation in the cocatalyzed processes are quite informative for further study.
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