Asymmetric α-Allylation of α-Branched Aldehydes with Allyl Alcohols by Synergistic Catalysis Using an Achiral Palladium Complex and a Chiral Primary Amino Acid

Highly enantioselective direct alpha-allylation of alpha-branched aldehydes with simple allyl alcohols was achieved by the combined use of an achiral transition-metal catalysis with a palladium complex and a chiral organocatalysis with a readily obtainable primary a-amino acid. Various alpha-allylated aldehydes possessing a stereo-controlled quaternary carbon stereogenic center were synthesized in high yields with high enantioselectivity.