期刊
SYNTHESIS-STUTTGART
卷 45, 期 6, 页码 703-718出版社
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0032-1318154
关键词
guanidines; catalysis; stereoselective synthesis; nucleophiles; domino reaction
资金
- Fonds der Chemischen Industrie, Germany
An overview of the most commonly used guanidine organocatalysts and their applications in organic synthesis is presented. Privileged structures of open, monocyclic and bicyclic guanidines and guanidinium salts are showcased with prominent examples from the literature. Free guanidines have found widespread use as strong Bronsted base catalysts in asymmetric synthesis. Guanidinium salts are employed as weak Bronsted acids or hydrogen-bond-donor catalysts and chiral counterions. The nucleophilic and Lewis basic properties of guanidines are still rarely exploited, but, as of late, have been gaining increasing recognition.
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