Recent Advances in Metal-Catalyzed Asymmetric Mannich Reactions

In this review, recent works on metal-catalyzed asymmetric Mannich, aza-Henry and vinylogous Mannich reactions are described. The asymmetric Mannich reaction is one of the most powerful methodologies among the carbon-carbon bond-forming reactions, and provides direct access to a wide range of optically active natural products with useful biological properties.