Oxidative Rearrangements with Hypervalent Iodine Reagents

Hypervalent iodine chemistry is used as an important tool in synthetic and natural product chemistry. A number of hypervalent iodine reagents can be used to generate the functionalizations on various scaffolds by several chemical approaches including oxidation reactions, oxidative cyclization reactions, and rearrangements. Recently, these reagents have been employed to develop a variety of oxidative rearrangements. In this review article, various aspects of recently developed oxidative rearrangements using iodine(III) and iodine(V) reagents are described. 1Introduction 2Oxidative Rearrangements 2.11,2-Aryl Group Migrations 2.2Hofmann Rearrangements 2.2.1Hofmann Rearrangements without Cyclizations 2.2.2Hofmann Rearrangements with Cyclizations 2.3Ring Contractions 2.4Ring Expansions 2.5Rearrangement of Tertiary Alcohols 2.6Wagner-Meerwein Rearrangements 2.7Domino Reactions 3Summary