期刊
SYNTHESIS-STUTTGART
卷 45, 期 3, 页码 396-405出版社
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0032-1317964
关键词
5-azidomethyl-2 '-deoxyuridine; microwave irradiation; click chemistry; EPR; antibacterial
A series of novel 5-(1,2,3-triazolyl)-2'-deoxyuridines were synthesized using a simple and convenient one-step synthetic procedure via the Huisgen reaction. The key step in these syntheses is a click reaction at the C-5 position under solvent free microwave irradiation and CuI as a catalyst. 5-Azidomethyl-2'-deoxyuridine was synthesized from thymidine and its click reactions with several alkynes provided triazole derivatives in good yields. The synthesized compounds showed only marginal antiviral activities [against human rhinovirus (HRV), hepatitis C virus (HCV) and HIV] and antibacterial activities against a series of Gram positive and Gram negative bacteria. Evaluation of fluorescence properties of pyrene-modified and EPR studies of nitroxyl spin-labeled deoxyuridines demonstrate the applicability of these compounds as valuable analytical tools.
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