期刊
SYNTHESIS-STUTTGART
卷 45, 期 12, 页码 1667-1674出版社
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0033-1338744
关键词
isothiocyanates; phenyl chlorothionoformate; amine; one-pot process; two-step approach
资金
- Natural Science Foundation of China [21002009]
- Major Program for the Natural Science Research of Jiangsu Colleges and Universities [12KJA150002]
- Jiangsu Key Laboratory of Advanced Catalytic Materials and Technology [BM2012110]
- Scientific and Technological Project of Changzhou [CJ20115019]
- Priority Academic Program Development (PAPD) of Jiangsu Higher Education Institutions
- Qing-Lan Project of Jiangsu Province
A facile and efficient synthesis of isothiocyanates from amines is described. This method involves the reaction of amines with phenyl chlorothionoformate in the presence of solid sodium hydroxide by either a one-pot process or a two-step approach. The one-pot process is useful for preparing alkyl and electron-rich aryl isothiocyanates, whereas the two-step approach is more versatile, working very well not only for alkyl and electron-rich aryl isothiocyanates, but also for highly electron-deficient aryl and heterocyclic isothiocyanates.
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