期刊
SYNTHESIS-STUTTGART
卷 44, 期 13, 页码 2005-2012出版社
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0031-1291145
关键词
amino acids; click chemistry; cycloaddition; coumarins; fluorescence labeling; peptides
资金
- Deutsche Forschungsgemeinschaft
Pechmann condensation is a straightforward protocol for the synthesis of alkynyl- and azido-substituted 7-(dialkylamino)coumarins, which can be coupled to amino acid and peptide derivatives by copper-catalyzed [3+2]-cycloaddition (click reaction) in high yield. This allows the introduction of these efficient fluorescence labels into biologically relevant molecules.
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