期刊
SYNTHESIS-STUTTGART
卷 44, 期 4, 页码 619-627出版社
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0031-1289663
关键词
acylation; arylation; catalysis; coupling; heterocycles; indoles; Lewis acids; palladium
资金
- CSIR, New Delhi
An efficient two-step approach, comprising the Friedel-Crafts reaction of 2-bromobenzoyl chlorides with indoles to give 3-(2-bromobenzoyl) indoles and their palladium-catalyzed intramolecular direct arylation to give indenoindolones, has been developed. 3-(2-Bromobenzoyl) indoles were crucial intermediates; the method was successful with N-unprotected or N-protected indoles. This approach affords a convenient preparation of diverse substituted and functionalized indenoindolones in good to high yields from easily accessible starting materials. Several moieties, which are commonly integrated into bioactive compounds, can be incorporated with ease by this synthesis.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据