期刊
SYNTHESIS-STUTTGART
卷 44, 期 9, 页码 1304-1307出版社
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0031-1289712
关键词
gamma,delta-unsaturated esters; copper; allylic alkylation; ketene silyl acetal; regioselectivity
资金
- JSPS
- MEXT [B01]
- Grants-in-Aid for Scientific Research [21350020, 24685015, 21750086] Funding Source: KAKEN
Copper-catalyzed allylic alkylation of ketene silyl acetals proceeded with excellent gamma-E-selectivity. Efficient alpha-to-gamma chirality transfer with anti-selectivity occurred in the reaction of enantioenriched secondary allylic phosphates, affording enantioenriched beta-branched gamma,delta-unsaturated esters. The reaction was readily scalable and highly reliable in terms of product yield and stereoselectivities.
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