TADDOL-Derived Phosphonites, Phosphites, and Phosphoramidites in Asymmetric Catalysis

In metal-based asymmetric catalysis, desirable attributes for chiral ligands include low cost, simplicity of synthesis, and ease of variation to enable fine-tuning of a particular transformation. TADDOL-derived phosphonites, phosphites, and phosphoramidites constitute one family of chiral ligand that possesses these features. In recent times, these ligands have excelled in a wide range of catalytic asymmetric reactions. This review article summarizes progress in this area.