期刊
SYNTHESIS-STUTTGART
卷 -, 期 18, 页码 3126-3130出版社
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0030-1257859
关键词
bis-C-glycoside; isoflavone; DIB; p-toluenesulfonic acid; oxidative rearrangement
This paper describes the first successful synthesis of two isoflavone bis-C-glycosides, genistein and orobol 6,8-di-C-beta-D-glucopyranosides from phloroacetophenone bis-C-glycoside in total yields of 27 and 19%, respectively, using a four-step reaction: direct C-glycosylation of phloroacetophenone with unprotected D-glucose; chalcone synthesis by aldol condensation; acetal synthesis by oxidative rearrangement using DIB and p-TsOH; and formation of the isoflavone ring using HCl, without protection of the glucose moiety.
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