期刊
SYNTHESIS-STUTTGART
卷 -, 期 17, 页码 2949-2956出版社
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0030-1258137
关键词
Pictet-Spengler reaction; gem-dibromomethylarenes; tetrahydroisoquinolines; isoindoloisoquinolinones; microwave irradiation
A new variant of the Pictet-Spengler reaction has been developed using gem-dibromomethylarenes as aldehyde surrogates to afford a variety of tetrahydroisoquinoline and isoindoloisoquinolone ring systems in good yields. These systems comprise important motifs in naturally occurring bioactive substances.
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