期刊
SYNTHESIS-STUTTGART
卷 -, 期 16, 页码 2763-2766出版社
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0029-1218835
关键词
natural products; halogenation; bromine; regioselectivity; coumarins
资金
- Spanish Ministry [PI061457, P509/00501]
- Xunta da Galicia [PXIB20304PR]
- Fundacao de Ciencia e Tecnologia [SFRH/BD/61262/2009]
Regioselective syntheses of 3-arylcoumarins possessing a bromine substituent either on the 3-aryl ring, the coumarin moiety or on a lateral chain of a coumarin is reported. The regioselectivity is influenced by the substituents present in the substrates. Two different bromination methods are described and compared. Perkin condensation of 5-methylsalicylaldehyde and phenylacetic acid or para-methoxyphenylacetic acid affords the desired coumarins. Three different bromine substitution patterns are accessed starting from 5-methylsalicylaldehyde.
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