期刊
SYNTHESIS-STUTTGART
卷 -, 期 20, 页码 3353-3374出版社
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0029-1216998
关键词
activated cyclopropanes; cyclizations; cycloadditions; isomerizations; stereoselective synthesis
资金
- EPFL
Activated cyclopropanes, such as vinyl and carbonyl cyclopropanes, are useful building blocks in organic chemistry due to their exceptional reactivity. This review focuses on the use of cyclopropyl carbonyls and imines in cyclization and cycloaddition reactions for the synthesis of cyclic compounds. Cycloisomerization and other cyclization reactions are treated first, followed by formal cycloaddition reactions and applications in total synthesis. For each class of reactions, key pioneering works are briefly presented and emphasis is then set on recent results. Indeed, the utility of activated cyclopropanes in organic synthesis has increased significantly in the last few years by combining modern catalytic methods with the well-established reactivity of these building blocks. Together with progress in the synthesis of the cyclopropanes, these new methods allowed a better control over the diastereoselectivity and enantioselectivity of the reactions as well as their use for the synthesis of complex natural products. 1 Introduction and Scope of the Review 2 Cyclization Reactions 2.1 Nucleophile Attached to the Carbonyl 2.2 Nucleophile Attached to the Cyclopropane 3 Cyclization Reactions Involving Incorporation of Exogenous Atom(s) 4 Formal [3+2]-Cycloaddition Reactions 4.1 With Olefins 4.2 With Aldehydes and Ketones 4.3 With Imines and Nitriles 4.4 With Other Electrophiles 5 Other Cycloaddition Reactions 5.1 [3+3]-Cycloaddition Reactions 5.2 [4+3]-Cycloaddition Reactions. 6 Applications in Total Synthesis 7 Conclusion
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