期刊
SYNTHESIS-STUTTGART
卷 -, 期 4, 页码 694-700出版社
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0029-1218583
关键词
amides; copper; cyclizations; lactams; radical reactions
资金
- Ministero della Istruzione, dell'Universita e della Ricerca (MIUR)
Atom transfer radical cyclization (ATRC) of N-alkyl N-allyl dichloroamides to gamma-lactams, catalyzed by `naked' CuCl, worked efficiently in DMF, whereas, when the same dichloroamides were N-sulfonylated, DMF needed to be replaced by acetonitrile. The outcome of the cycloisomerization with N-substituted N-allyl trichloroacetamides was less affected by solvent choice, although for an effective reaction to occur, the solvent had to dissolve the cuprous salt. Catalyst loading ranged between 5 and 20 mol%.
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