4.4 Article

Electrophile-Promoted Cyclization of Propargylic Amides

期刊

SYNLETT
卷 26, 期 4, 页码 479-483

出版社

GEORG THIEME VERLAG KG
DOI: 10.1055/s-0034-1379320

关键词

propargylic amides; electrophile; cyclization; oxazines; oxazolines

资金

  1. European Social Fund under the Global Grant measure [VP1-3.1-SMM-07-K-01-002]

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Electrophilic cyclization of N-(3-arylprop-2-ynyl)amides to functionalized 4H-1,3-oxazines is described. It was found that the presence of an electron-rich aryl group next to the triple bond is crucial for a smooth and highly regioselective 6-endo-dig ring closure process.

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