Magnetic Nano Fe3O4 Catalyzed Solvent-Free Stereo- and Regioselective Aminolysis of Epoxides by Amines; a Green Method for the Synthesis of β-Amino Alcohols

We report the use of magnetic nano Fe3O4 as a mild heterogeneous catalyst for the aminolysis of epoxides with amines. The approach constitutes a green method for the formation of a variety of beta-amino alcohols with very high stereo- and regioselectivity under solvent-free and ambient reaction conditions. The aminolysis of chiral epoxides with amines gave the corresponding chiral beta-amino alcohols with complete inversion of stereochemistry. The magnetic nano Fe3O4 catalyst can be easily recovered and recycled.