期刊
SYNLETT
卷 24, 期 6, 页码 733-736出版社
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0032-1318314
关键词
photochemistry; photocleavable linker; solid-phase synthesis; amino acid derivative; peptides
资金
- Pioneer Research Center Program, through the National Research Foundation of Korea
- Ministry of Education, Science and Technology [2012-0000460]
A photocleavable linker, N-(9-fluorenylmethyloxycarbonyl)-3-amino-3-(4,5-dimethoxy-2-nitrophenyl) propionic acid was synthesized from veratraldehyde, with simple reaction and separation steps. This linker was stable under the normal solid-phase peptide synthesis conditions and rearranged to a labile form when irradiated with UV light (lambda = 365 nm). A model peptide sequence (YGGFL) was synthesized and released from solid supports with high efficiency by UV irradiation.
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