期刊
SYNLETT
卷 -, 期 4, 页码 589-594出版社
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0031-1290340
关键词
N-alkynylimidazoles; 1,1-dibromo-1-alkenes; copper; cross-coupling reaction; alkynylation
资金
- National Natural Science Foundation of China [31071720]
A simple and efficient method for the synthesis of N-alkynylheteroarenes from 1,1-dibromo-1-alkenes was developed via a copper-catalyzed cross-coupling reaction. Generally superior yields and functional-group tolerance were obtained with TMEDA as ligand using imidazole and benzimidazole substrates in dioxane.
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