期刊
SYNLETT
卷 -, 期 5, 页码 760-764出版社
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0031-1290532
关键词
cross-coupling; regioselectivity; alkaloids; alkynes; amines
资金
- CSIR, New Delhi, India [01(2138)/07/EMR-II]
Direct cross-coupling between N-methyltetrahydroisoquinolines and alkynes using CuI-DEAD is presented. It affords the regioselective C-1-alkynylated products in good yield. This regioselectivity is in contrast to the results reported earlier in the reaction of N,N-dimethylbenzyl amine where the N-methyl alkynylated product was formed exclusively or predominantly. The C-1-substituted propargylic isoquinolines were easily reduced to phenethylisoquinolines with Pd/C. This reaction sequence provides a short route to synthesize methopholine, homolaudanosine and other phenethylisoquinoline alkaloids.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据