期刊
SYNLETT
卷 -, 期 19, 页码 2768-2772出版社
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0032-1317708
关键词
C-H oxidation; functionalization; aliphatic; non-heme iron; natural product diversification; biosynthesis; cafestol
资金
- National Science Foundation under the CCI Center for Selective C-H Functionalization [CHE-1205646]
- NIH [GM36700]
- Division Of Chemistry
- Direct For Mathematical & Physical Scien [1205646] Funding Source: National Science Foundation
The tricalysiolides are a recently isolated class of diterpene natural products featuring the carbon backbone of the wellknown coffee extract, cafestol. Herein we validate the use of our non-heme iron complex, Fe(PDP), as an oxidative tailoring enzyme mimic to test the proposal that this class of natural products derives from cafestol via cytochrome P-450-mediated furan oxidation. Thereafter, as predicted by computational analysis, C-H oxidation derivatization studies provided a novel 2 degrees alcohol product as a single diastereomer.
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