期刊
SYNLETT
卷 -, 期 15, 页码 2181-2184出版社
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0030-1261197
关键词
heterocycles; natural products; cyclisation; antibiotics; lactams
资金
- EPSRC [GR/T20380/01]
- Korea Research Foundation
- Korean Government (MOEHRD) [KRF-2006-352-C00044]
- British Commonwealth Scholarship Commission UK [INCF-2008-68]
- EC [FP7/REGPOT-2009-1/BioSupport]
The synthesis of a lactam-lactone bicyclic system containing a pyroglutamate subunit proceeds to give the fused lactone system, which is favoured over the spirocyclic lactone alternative. These systems display no or weak antibacterial activity against the test organisms S. aureus and E. coli.
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