Total Synthesis of Amphilectane-Type Diterpenoid (±)-7-Isocyanoamphilecta-11(20),15-diene

The total synthesis of amphilectane-type diterpenoid (+/-)-7- isocyanoamphilecta-11(20),15-diene, isolated from the tropical marine sponge Cymbastela hooperi, was achieved. The synthesis involves construction of a cis-decalin ring by an intramolecular Diels-Alder reaction and construction of an all-trans-perhydrophenalene ring by an intramolecular Michael reaction as the key steps.