4.4 Article

One-Pot Three-Component Solvent-Free Cyanoaroylation of Aldehydes Using Potassium Hexacyanoferrate(II) as an Environmentally Benign Cyanide Source

期刊

SYNLETT
卷 -, 期 14, 页码 2164-2168

出版社

GEORG THIEME VERLAG KG
DOI: 10.1055/s-0030-1258495

关键词

aldehydes; cyanohydrins; green chemistry; multicomponent reaction; nucleophilic addition

资金

  1. National Natural Science Foundation of China [20772096]
  2. Key Laboratory of Eco-Environment-Related Polymer Materials (Northwest Normal University)
  3. Ministry of Education of China

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An efficient method for one-pot three-component solvent-free cyanoaroylation of aldehydes using potassium hexacyanoferrate(II) as an environmentally benign cyanide source and triethylamine as a catalyst has been described. This method has advantages of not using strongly toxic cyanating agents and volatile organic solvents. In addition, the product was obtained in high yield using a simple workup procedure.

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