期刊
SYNLETT
卷 -, 期 5, 页码 749-752出版社
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0029-1219344
关键词
microreactor; flow chemistry; pyrrolidine; dipolar cycloaddition; solid-supported reagents
资金
- Cambridge European Trust
- Ralph Raphael Studentship award
- Royal Society
- BP endowment
- EPSRC [EP/G028125/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [EP/G028125/1] Funding Source: researchfish
The generation and subsequent use of unstabilised azomethine ylides in dipolar cycloaddition reactions within a flow microreactor is demonstrated. The 3-nitropyrrolidines produced were furthermore subjected to chemoselective hydrogenation reactions using the H-Cube (R) system. To ensure product purities in excess of 90-95%, immobilised scavengers were successfully employed.
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