期刊
SYNLETT
卷 -, 期 1, 页码 81-84出版社
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0029-1218528
关键词
catalysis; cross-coupling; heterocycles; palladium; regioselectivity; silane
资金
- WACKER Chemie AG
The regioselectivity of the Hiyama cross-coupling reaction at various dihalo-substituted heterocycles has been Studied. Methyl 2,3-dibromo-5-furancarboxylate and n-octyltrifluorosilane were employed to find optimum reaction conditions [CsF; Pd(2)dba(3)/P(2-furyl)(3) as catalyst, 80-150 degrees C in toluene or benzene] for the desired transformation. Subsequent experiments with the title compounds and with different primary alkyltrifluorosilanes illustrate the generality of this regiochemical process.
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